Journal of Science and Technology

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Research Article Fucoidan and Fucoxanthin Ameliorate Cardiac Function of Aging Canine
(Trường Đại học Nguyễn Tất Thành (Tạp chí Khoa học công nghệ NTT), 2017-10-15) Chih-Hung Tsai; Phan Nam; Yen-Chang Lin
In this study, fucoidan in combination with fucoxanthin were used to enhance the impaired cardiac systolic and diastolic function in aging canine model. Materials and Methods: Aging canines were fed with fucoidan (125 mg kgG1) and fucoxanthin (125 mg kgG1) for 3 months. Echo cardiography was used to compute Tei index and related parameter such as E / E`, E` / A` and isovolumetric relaxation time (IVRT), isovolumetric contraction time (IVCT) was calculated using the Doppler model. T-Test was used to compare echo parameters. Data were displayed as Mean±SD. SPSS was used for statistical analysis. Results: IVRT and IVCT were shortened with 15.78±3.71 and 24.53±6.71%, respectively after fucoidan and fucoxanthin treatment, suggested that these two phytochemical compounds have cardioprotective effects in aging canine subjects with degenerative valve disease. Conclusion: After 3 consecutive months of Fucoidan and fucoxanthin usage, the cardiac function of aging canine was improved. Fucoidan and fucoxanthin may be considered as a potential treatment or supplement to aging canine subjects with abnormality in cardiac function.