The update to this guideline considers the transition from critical emergency-response activities to longer-term, sustained COVID-19 disease prevention, control and management, and a shift towards integration of IPC activities into routine systems and practices. This includes an emphasis on standard and transmission-based precautions in health-care settings, and the adoption of public health practices for community settings. Updated recommendations for health-care facilities include a focus on the hierarchy of control measures, standard and transmission-based precautions and water, sanitation and hygiene measures. The prevention of health care-associated infections involves a multi-pronged and multi-factorial approach that includes infection prevention and control and occupational health and safety measures.