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Fabrication of Rosemary Essential Oil Nanoemulsions via Phase Inversion Temperature
(Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University; AOTA International Joint Stock Company, Ho Chi Minh City, 2019-10) Le, Minh Thuy Duong, ST; Luu, Xuan Cuong, PhD; Nguyen, Dinh Phuc, MD
This research aimed to develop a rosemary essential oil nanoemulsion using the phase inversion temperature method. Various factors influencing emulsion formation and characteristics, including oil phase composition, surfactant type, and mixing temperature, were investigated. The phase inversion temperature of the system was determined to be approximately 70°C. Among the surfactants evaluated, Tween 80 exhibited exceptional performance in producing nanoemulsions. Nanoemulsions containing up to 10% oil phase could be successfully formulated using 10% Tween 80. Stability testing indicated that the rosemary nanoemulsion remained stable for over 30 days. These findings hold potential for expanding the utilization of rosemary essential oil.